Park SJ, Kim Y, Yang SM, Henderson MJ, Yang W, Lindahl M, Urano F, Chen Y. Discovery of novel endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome. Proc Natl Acad Sci 2019



Our PNAS paper is highlighted by Nature Reviews Nephrology.






Park SJ, Kim Y, Chen Y. Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology. Pediatr Nephrol  2018




Kim Y, Park SJ, Manson SR, Carlos M, Kidd K, Thiessen-Philbrook H, Perry R, Liapis H, Kmoch S, Parikh CR, Bleyer AJ, Chen Y. Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. JCI Insight 2(23): e92896 2017



Kim Y, Park SJ, Chen Y. Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology and therapeutic roles. Transl 188: 1–9 2017 [Featured New Investigator Series]



Mutneja A, Cossey LN, Liapis H, Chen Y. A rare case of renal thrombotic microangiopathy associated with Castleman’s disease. BMC Nephrol 18: 57, 2017




Kim Y, Lee H, Manson SR, Lindahl M, Evans B, Miner JH, Urano F, Chen Y. Mesencephalic astrocyte-derived neurotrophic factor as a urine biomarker for endoplasmic reticulum stress-related kidney diseases. J Am Soc Nephrol 27: 2974-2982 2016



Singh S, Manson SR, Lee H, Kim Y, Liu T, Guo QS, Geminiani JJ, Austin PF, and Chen Y. Tubular overexpression of angiopoietin-1 attenuates renal fibrosis. PLOS ONE 11(7): e0158908 2016




Chen Y, Liapis H. Focal segmental glomerulosclerosis: molecular genetics and targeted therapies. [Corresponding author] BMC Nephrol 16: 101, 2015




Chen Y, Zhou YF, Go G, Marmerstein JT, Kikkawa Y, Miner J. Laminin β2 gene missense mutation produces endoplasmic reticulum stress in podocytes.  J Am Soc Nephrol. 24: 1223-1233 2013




Chen Y, Marcos LA, Liapis H, Steinberg TH, Morrison AR. An unusual cause of membranous glomerulonephritis in a patient with HIV.  Int Urol Nephrol. 44(3): 983-6 2012




Chen Y, Miner J. Glomerular basement membrane and related glomerular disease.  Transl 160: 291–297 2012 [Corresponding author, Featured New Investigator Series]




Chen Y, Kikkawa Y, Miner J. A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion.  J Am Soc Nephrol. 22: 849-858 2011 [Cover illustration]




Chen Y, Donnelly E, Kobayashi H, DeBusk LM and Lin PC. Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum. 52(5): 1585-1594 2005


[Editorial comments]: Pap T and Distler O. Linking angiogenesis to bone destruction in arthritis.  Arthritis Rheum. 52(5): 1346-1348


Chen JX, Chen Y, DeBusk LM, Lin W, Lin PC. Dual functional roles of Tie2/angiopoietin in TNF-alpha-mediated angiogenesis.  Am J Physiol Heart Circ Physiol. 287(1): H187-195 2004




DeBusk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC. Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis.  Arthritis Rheum. 48(9): 2461-2471 2003



Chen Y, Rosloniec E, Price J, Boothby M, Chen J. Constitutive expression of Bcl-xL in the T lineage attenuates collagen-induced arthritis in Bcl-xL transgenic mice.  Arthritis Rheum. 46(2): 514-521 2002




Chen Y, Rosloniec E, Goral MI, Boothby M, Chen J. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2Rb/IL-4Ra chimeric cytokine receptor transgene.  J. Immunol. 166(6): 4163-4169 2001