Park SJ, Kim Y, Yang SM, Henderson MJ, Yang W, Lindahl M, Urano F, Chen Y. Discovery of novel endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome. Proc Natl Acad Sci 2019

 

 

Our PNAS paper is highlighted by Nature Reviews Nephrology.

 

 

 

 

 

Park SJ, Kim Y, Chen Y. Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology. Pediatr Nephrol  2018

 

 

Kim Y, Park SJ, Manson SR, Carlos M, Kidd K, Thiessen-Philbrook H, Perry R, Liapis H, Kmoch S, Parikh CR, Bleyer AJ, Chen Y. Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. JCI Insight 2(23): e92896 2017

 

 

Kim Y, Park SJ, Chen Y. Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology and therapeutic roles. Transl 188: 1–9 2017 [Featured New Investigator Series]

 

 

Mutneja A, Cossey LN, Liapis H, Chen Y. A rare case of renal thrombotic microangiopathy associated with Castleman’s disease. BMC Nephrol 18: 57, 2017

 

 

Kim Y, Lee H, Manson SR, Lindahl M, Evans B, Miner JH, Urano F, Chen Y. Mesencephalic astrocyte-derived neurotrophic factor as a urine biomarker for endoplasmic reticulum stress-related kidney diseases. J Am Soc Nephrol 27: 2974-2982 2016

 

 

Singh S, Manson SR, Lee H, Kim Y, Liu T, Guo QS, Geminiani JJ, Austin PF, and Chen Y. Tubular overexpression of angiopoietin-1 attenuates renal fibrosis. PLOS ONE 11(7): e0158908 2016

 

 

Chen Y, Liapis H. Focal segmental glomerulosclerosis: molecular genetics and targeted therapies. [Corresponding author] BMC Nephrol 16: 101, 2015

 

 

 

Chen Y, Zhou YF, Go G, Marmerstein JT, Kikkawa Y, Miner J. Laminin β2 gene missense mutation produces endoplasmic reticulum stress in podocytes.  J Am Soc Nephrol. 24: 1223-1233 2013

 

 

Chen Y, Marcos LA, Liapis H, Steinberg TH, Morrison AR. An unusual cause of membranous glomerulonephritis in a patient with HIV.  Int Urol Nephrol. 44(3): 983-6 2012

 

 

 

Chen Y, Miner J. Glomerular basement membrane and related glomerular disease.  Transl 160: 291–297 2012 [Corresponding author, Featured New Investigator Series]

 

 

 

Chen Y, Kikkawa Y, Miner J. A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion.  J Am Soc Nephrol. 22: 849-858 2011 [Cover illustration]

 

 

 

Chen Y, Donnelly E, Kobayashi H, DeBusk LM and Lin PC. Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum. 52(5): 1585-1594 2005

[Editorial comments]: Pap T and Distler O. Linking angiogenesis to bone destruction in arthritis.  Arthritis Rheum. 52(5): 1346-1348

 

Chen JX, Chen Y, DeBusk LM, Lin W, Lin PC. Dual functional roles of Tie2/angiopoietin in TNF-alpha-mediated angiogenesis.  Am J Physiol Heart Circ Physiol. 287(1): H187-195 2004

 

 

 

DeBusk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC. Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis.  Arthritis Rheum. 48(9): 2461-2471 2003

 

 

Chen Y, Rosloniec E, Price J, Boothby M, Chen J. Constitutive expression of Bcl-xL in the T lineage attenuates collagen-induced arthritis in Bcl-xL transgenic mice.  Arthritis Rheum. 46(2): 514-521 2002

 

 

Chen Y, Rosloniec E, Goral MI, Boothby M, Chen J. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2Rb/IL-4Ra chimeric cytokine receptor transgene.  J. Immunol. 166(6): 4163-4169 2001