Our PNAS paper is highlighted by Nature Reviews Nephrology today! Congrats, Sun-Ji and Yeawon!
A new study first-authored by Sun-Ji Park, found a new class of drugs that shows great promise in the treatment of nephrotic syndrome (NS) resulting from podocyte endoplasmic reticulum (ER) dysfunction. NS is a leading cause of chronic kidney disease affecting over 500 million people worldwide. Damage to podocytes, the highly specialized epithelial cells that […]
Maggie just received an Investigator Matching Micro Grant funded by the Center for Drug Discovery (CDD) at Washington University for her proposal titled Development of a Novel Biotherapeutic Protein to Treat Endoplasmic Reticulum Stress-Mediated Kidney Disease. Although accumulating evidence has highlighted the important role of endoplasmic reticulum (ER) stress in the pathogenesis of various glomerular […]
Yeawon and Maggie were among the Washington University innovators and inventors honored at the 2nd Annual Celebration of Inventors on May 7, 2019, at Innovation Hall in the Cortex Innovation Community. The event was sponsored by the Office of Technology Management (OTM). Recognized at the celebration were a total of 117 faculty members who were […]
A U.S. patent was issued on 12/18/2018 to Division of Nephrology faculty member Ying (Maggie) Chen, MD, PhD, and co-inventor Yeawon Kim for their discovery of noninvasive biomarkers that have the potential to help diagnose certain human kidney diseases in their earliest stages of development. The patent is based on their research published in JCI […]
Sun-Ji presented her poster "Inhibiting podocyte endoplasmic reticulum stress-mediated apoptosis to treat genetic nephrotic syndrome" on 10/27/2018 at the kidney Week 2018.
Sun-Ji published an invited review "Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology" in Pediatric Nephrology. Congrats!
Washington University Office of Technology Management filed a provisional patent application entitled “Compositions and methods for treating and preventing endoplasmic reticulum (ER) stress-mediated kidney diseases" on 6/19/2018. The inventors include Ying Chen, Sun-Ji Park, Yeawon Kim and Fumihiko Urano.
Yeawon's study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in the journal JCI Insight, December 7, 2017. The ER is the central site for folding, posttranslational modifications and transport of secretory and membrane proteins. When there is a mismatch between the load of unfolded/misfolded proteins and the folding […]
Sun-Ji's poster entitled, “Targeting Podocyte Endoplasmic Reticulum Calcium Depletion to Treat Nephrotic Syndrome” has been selected as a “topic of interest” for students and residents. As a part of the ASN Kidney STARS program, 10 participants and their mentors visited Sun-Ji's poster today.
Congratulations to Assistant Professor of Medicine Ying (Maggie) Chen, MD, PhD, who has been awarded a five-year $1.52M total costs, R01 grant from the NIH to fund a research project titled Podocyte Endoplasmic Reticulum Stress and Nephrotic Syndrome. Nephrotic syndrome (NS), characterized by heavy proteinuria and increased risk of loss of kidney function, causes serious […]
A review article by the group of Ying Maggie Chen, MD, PhD, Assistant Professor of Medicine, Washington University School of Medicine, Division of Nephrology, was published as part of the Featured New Investigator series in the journal Translational Research. The article, Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, […]