We have received a $1.8M DoD grant

We have received a $1.8M DoD grant
Maggie is awarded a $1.8 million grant from the U.S. Department of Defense for her study “Develop Novel Podocyte Endoplasmic Reticulum (ER) Calcium Stabilizers to Treat Focal Segmental Glomerulosclerosis (FSGS).” FSGS is the most common primary glomerulopathy leading to renal failure and disproportionately affects African-Americans, a highly represented population among military personnel and Veterans. While […]

We are awarded a $300K WUSM-Mallinckrodt Challenge grant

We are awarded a $300K WUSM-Mallinckrodt Challenge grant
Maggie is the recipient of a 2-year, $300,000 Mallinckrodt Challenge Grant for her study “Targeting Podocyte Dysfunctional Ryanodine Receptor to Treat Nephrotic Syndrome.” The overall goals of this proposal are to determine the molecular mechanisms underlying increased podocyte endoplasmic reticulum (ER) calcium efflux under ER stress. The proposed study could lead to a significant leap […]

Sun-Ji’s paper is published in PNAS

Sun-Ji’s paper is published in PNAS
A new study first-authored by Sun-Ji Park, found a new class of drugs that shows great promise in the treatment of nephrotic syndrome (NS) resulting from podocyte endoplasmic reticulum (ER) dysfunction. NS is a leading cause of chronic kidney disease affecting over 500 million people worldwide. Damage to podocytes, the highly specialized epithelial cells that […]

Maggie Receives Center for Drug Discovery Investigator Matching Grant

Maggie Receives Center for Drug Discovery Investigator Matching Grant
Maggie just received an Investigator Matching Micro Grant funded by the Center for Drug Discovery (CDD) at Washington University for her proposal titled Development of a Novel Biotherapeutic Protein to Treat Endoplasmic Reticulum Stress-Mediated Kidney Disease. Although accumulating evidence has highlighted the important role of endoplasmic reticulum (ER) stress in the pathogenesis of various glomerular […]

Yeawon and Maggie are Honored at OTM’s Annual Celebration of Inventors

Yeawon and Maggie are Honored at OTM’s Annual Celebration of Inventors
Yeawon and Maggie were among the Washington University innovators and inventors honored at the 2nd Annual Celebration of Inventors on May 7, 2019, at Innovation Hall in the Cortex Innovation Community.  The event was sponsored by the Office of Technology Management (OTM). Recognized at the celebration were a total of 117 faculty members who were […]

Our patent is issued by the USPTO office

Our patent is issued by the USPTO office
A U.S. patent was issued on 12/18/2018 to Division of Nephrology faculty member Ying (Maggie) Chen, MD, PhD, and co-inventor Yeawon Kim for their discovery of noninvasive biomarkers that have the potential to help diagnose certain human kidney diseases in their earliest stages of development. The patent is based on their research published in JCI […]

WU OTM filed a patent for our invention

WU OTM filed a patent for our invention
Washington University Office of Technology Management filed a provisional patent application entitled “Compositions and methods for treating and preventing endoplasmic reticulum (ER) stress-mediated kidney diseases" on 6/19/2018. The inventors include Ying Chen, Sun-Ji Park, Yeawon Kim and Fumihiko Urano.

Yeawon’s paper on CRELD2 is published in JCI Insight

Yeawon’s paper on CRELD2 is published in JCI Insight
Yeawon's study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in the journal JCI Insight, December 7, 2017. The ER is the central site for folding, posttranslational modifications and transport of secretory and membrane proteins. When there is a mismatch between the load of unfolded/misfolded proteins and the folding […]