Ying (Maggie) Chen, MD, PhD

Principal Investigator

I am an Assistant Professor of Medicine and Director of Nephrotic Syndrome Clinic. My long-term goal is to investigate the role of ER stress in various kidney diseases. Currently our research focuses on three major areas. 1. Define molecular mechanisms underlying genetic determinants of ER stress-mediated kidney diseases by utilizing a combination of stably transfected cell lines, inducible transgenic, conditional knock-out and knock-in animal models, next generation sequencing data, as well as biospecimen including hiPSCs derived from human patients; 2. Discover and validate ER stress biomarkers in kidney disease patients; 3. Identify ER stress modulators by employing high throughput drug screening. Ultimately, we hope to develop highly-targeted clinical trials to treat kidney disease patients caused by ER stress. As a physician-scientist and junior investigator, my research achievements have been acknowledged by multiple career development awards from NIH, American Society of Nephrology, Central Society for Clinical and Translational Research (CSCTR), Doris Duke Charitable Foundation, Nephrotic Syndrome Study Network (NEPTUNE), and the Children’s Discovery Institute.

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