Author: Ying Chen

Maggie reviewed for Glomerular Diseases: 1401 Glomerular Diseases: Mechanisms, including Podocyte Biology.

On 5/22/2024, Maggie served in the review panel for VA Merit Grant proposals.

Maggie gave a lecture, Therapeutics in Kidney Disease, to WashU MD/Ph.D students on 5/7/2024

We are awarded a one-year grant entitled “Personalized kidney organoid modeling to develop novel treatment for uromodulin-associated chronic kidney disease” from WashU Center of Regenerative Medicine.

March 13-15, 2024, Maggie went to Washington DC for Ben J. Lipps Research Fellowship and Transition to Independence grant review.

On Nov.2, 2023, Chuang presents “MANF stimulates autophagy and restores mitochondrial homeostasis to treat uromodulin-associated nephropathy” in the 2023 ASN national meeting at Philadelphia (TH-OR62). Chuang and our great collaborator Dr. Anthony Bleyer are the first two speakers in this session.

In the ASN early program, Glomerular Diseases: 2023 Update, Maggie discusses “Nephrotic syndrome diagnosis and management: traditional and novel approaches”.

Our proposal, “Targeting a Novel Receptor to Treat Uromodulin-Associated Chronic Kidney Disease” is selected for a Wash U Center for Drug Discovery Match Grant.

Maggie reviewed for the category: CKD (Non-Dialysis): 2303 CKD (Non-Dialysis): Mechanisms

On 5/24/2023, Maggie is invited to present “Endoplasmic reticulum stress in nephrotic syndrome” in the 14th Biennial International Podocyte Conference, held in Philadelphia, PA.

Chuang’s minireview paper is published in Nephron. It is also highlighted by ASN in the Loop today.

Maggie gave a talk, “Targeting ER for novel therapeutics and monitoring in acute kidney injury” at UAB/UCSD O’Brien Kidney Center Symposium on 3/7/2022.

Chuang has published his review “Endoplasmic Reticulum-Associated Biomarkers for Molecular Phenotyping of Rare Kidney Disease” in International Journal of Molecular Sciences today

Sun-Ji’s review article “Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease: Pathogenesis and Therapeutic Targets” has been published in American Journal of Pathology this month.

Sun-Ji presented her research about discovery of novel podocyte ER calcium stabilizers on 11/9/2019 at the ASN national meeting. Congrats!

Our PNAS paper is highlighted by Nature Reviews Nephrology today! Congrats, Sun-Ji and Yeawon!

Sun-Ji presented her poster “Inhibiting podocyte endoplasmic reticulum stress-mediated apoptosis to treat genetic nephrotic syndrome” on 10/27/2018 at the kidney Week 2018.

Sun-Ji published an invited review “Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology” in Pediatric Nephrology. Congrats!

Washington University Office of Technology Management filed a provisional patent application entitled “Compositions and methods for treating and preventing endoplasmic reticulum (ER) stress-mediated kidney diseases” on 6/19/2018. The inventors include Ying Chen, Sun-Ji Park, Yeawon Kim and Fumihiko Urano.

Yeawon’s study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in the journal JCI Insight, December 7, 2017. The ER is the central site for folding, posttranslational modifications and transport of secretory and membrane proteins. When there is a mismatch between the load of unfolded/misfolded proteins and the folding […]

Sun-Ji’s poster entitled, “Targeting Podocyte Endoplasmic Reticulum Calcium Depletion to Treat Nephrotic Syndrome” has been selected as a “topic of interest” for students and residents. As a part of the ASN Kidney STARS program, 10 participants and their mentors visited Sun-Ji’s poster today.

Ying (Maggie) Chen, Assistant Professor of Medicine in the Division of Nephrology has been awarded a Children’s Discovery Institute (CDI) and Human Pluripotent Stem Cell (HPSC) Core Pilot Grant for her proposal Modeling Tubular Endoplasmic Reticulum Stress-induced Renal Fibrosis using Human Induced Pluripotent Stem Cells. Dr. Chen’s research focuses on the genetic factors responsible for […]

Assistant Professor of Medicine Ying (Maggie) Chen, MD, PhD, was an invited speaker at the Experimental Biology (EB) 2017 meeting, which attracts 14,000 scientists each year. This year’s meeting was held in Chicago, Ill, April 22-27. Dr. Chen presented her talk Podocyte ER stress and Podocytopathies in the “Diseases of the Endoplasmic Reticulum” session. This session included six […]

A case report by a team of Washington University nephrologists and pathologists from Arkana Laboratories may prove valuable in directing future treatment of Castleman’s Disease (CD) with renal involvement. The report, published in the journal BMC Nephrology, describes a patient presenting with a very rare, aggressive form of multicentric CD with renal thrombotic microangiopathy (TMA). […]

Angiopoietin-1 (Ang-1), a vascular growth factor secreted by kidney proximal tubular cells, pericytes and podocytes, is essential for regulating blood vessel development and repair after injury.  Ang-1 is also a promising therapeutic agent to target renal fibrosis, according to a study by WU researchers recently published in PLoSOne, As a result of injury to the […]

Certain environmental and genetic factors can disrupt endoplasmic reticulum (ER) function and result in a situation called “ER stress”, in which misfolded/unfolded proteins accumulate in the ER lumen.  Prolonged or intense ER stress contributes to the pathogenesis of a variety of glomerular and tubular diseases in humans, such as congenital nephrotic syndrome, familial focal segmental […]

Ying (Maggie) Chen MD, PhD and Andrew Malone MD are recipients of the inaugural Translational Innovation Grant. Their proposal entitled, “Targeting Podocyte Endoplasmic Reticulum Stress in Alport Syndrome,” aims to identify pathogenic mutations in collagen genes that lead to Alport’s syndrome. They will utilize whole-exome sequencing to identify patients with mutations, in collaboration with the […]

Ying (Maggie) Chen, MD, PhD, Assistant Professor of Medicine, Renal Division, has been awarded a Doris Duke Charitable Foundation Grant. The award is one of several that Dr. Chen has received in 2015, including an R03 grant from the NIH/NIDDK, an Early Career Development Award from the Central Society for Clinical and Translational Research (CSCTR) […]

Ying (Maggie) Chen MD, PhD, Assistant Professor in the Department of Medicine (Renal), has been selected as a recipient of a 2015 Early Career Development Award from the Central Society for Clinical and Translational Research. Maggie was one of five recipients to earn this award. Three awards went to the University of Chicago and one […]